The Effect of Curcuma Extract Emulsion as an Amara on Ghrelin Hormone Profiles and Increased Feed Consumption in Male Rats
DOI:
https://doi.org/10.36858/jkds.v14i1.1119Keywords:
amara, curcuma, ghrelin, hunger, elisaAbstract
Background : Curcuma (Curcuma xanthorrhiza Roxb.) contains curcuminoids and essential oils that aid bile and pancreatic function, thereby improving food absorption in the intestines and increasing appetite. However, the underlying biological mechanisms of the hormones that regulate hunger and satiety have not been extensively reported. This study aims to analyze the appetite-suppressing mechanism of curcuma rhizome extract emulsion by observing changes in ghrelin hormone levels in male Wistar rats. Methods : This study was an experimental study using a post-test only control group design. The test animals were divided into four groups: negative control (distilled water), and three treatment groups that received curcuma extract emulsion at different concentrations (10%, 20%, and 30%). The treatment was administered orally for 21 days. The parameters obtained included ghrelin levels in serum, which were analyzed using the ELISA method, while additional parameters included daily feed intake and weight change. The data obtained were analyzed using normality and homogeneity tests, followed by one-way ANOVA and post-hoc tests. Results: This study shows that administration of curcuma extract emulsion can enhance the effects of amara, as seen from increased feed intake and body weight, and by increased ghrelin levels when compared to the control. Conclusions: This study concluded that curcuma functions as an appetite stimulant through hormonal pathways, which has the potential to be developed as a phytopharmaceutical candidate to increase appetite through a mechanism-based approach.
References
Berdasarkan BMI Sesuai Kriteria World Health Organization pada Subjek Non Diabetes Melitus (DM)= The Relationship Between Insulin Resistance, Serum Ghrelin Level and Nutrition Status Based on BMI According to World Health Organization Criteria in Non Diabetes Melitus (DM) Subjects (Doctoral dissertation, Universitas Hasanuddin).
Al-hussaniy, H. A., & AL-Biati, H. A. (2022). The role of leptin hormone, neuropeptide Y, ghrelin and leptin/ghrelin ratio in Obesogenesis. Medical and Pharmaceutical Journal, 1(2), 52-63.
Ginieis, R., Abeywickrema, S., Oey, I., & Peng, M. (2022). Testing links of food-related olfactory perception to peripheral ghrelin and leptin concentrations. Frontiers in Nutrition, 9, 888608.
Hajishizari, S., Imani, H., Mehranfar, S., Saeed Yekaninejad, M., Mirzababaei, A., Clark, C. C., & Mirzaei, K. (2022). The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/obese women: a case–control study. BMC nutrition, 8(1), 37.
Handayani, E. (2022). Formulasi Susu Murni Dengan Infusa Temulawak (Curcuma Xanthorrhiza Roxb.) Sebagai Penambah Nafsu Makan. Parapemikir: Jurnal Ilmiah Farmasi, 11(1), 49-54.
Konuksever, Y. E., & Şahinduran, Ş. (2024). The Effects of Leptin and Ghrelin Hormones on Metabolism. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 12(3), 34-39.
Kumar, M. M. (2023). Eating Disorders in Youth with Chronic Health Conditions: Clinical Strategies for Early Recognition and Prevention. Nutrients, 15(17). https://doi.org/10.3390/nu15173672
Liu, Y., Jia, T., Ren, Y., Wang, Z., & Zhu, W. (2022). Roles of ghrelin and leptin in body mass regulation under food restriction based on the AMPK pathway in the red-backed vole, Eothenomys miletus, from Kunming and Dali regions. Animals, 12(23), 3333.
Kharbanda, C., Bansal, S., & Aneja, P. S. (2022). Role and Significance of Ghrelin and Leptin in Hunger, Satiety, and Energy Homeostasis. Journal of the Scientific Society, 49(1), 12–16. https://doi.org/10.4103/jss.jss_126_21.
Munawaroh, S. (2022). Efektifitas Temulawak Untuk Meningkatkan Berat Badan Balita.
Nissa, C., Mufidah, S. N., & Ulum, M. (2025). Comparison of temulawak (Curcuma xanthorrhiza Roxb.) and turmeric (Curcuma longa) powder drinks against adolescent diet and body weight. Jurnal Gizi Dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics), 13(1), 21. https://doi.org/10.21927/ijnd.2025.13(1).21-27
Novita, K. D. (2024). Pengaruh Kadar Leptin dan Ghrelin Serum terhadap Fungsi Pendengaran pada Obesitas dan Diabetes Mellitus Tipe II (Doctoral dissertation, Universitas Gadjah Mada).
Nuraidah, N., Putri, R., & Febriyani, P. A. (2025). Efektivitas Penggunaan Temulawak dan Madu untuk Meningkatkan Nafsu Makan pada Balita: The Effectiveness of Using Temulawak and Honey to Increase Toddlers' Appetite. Jurnal Ilmiah Kebidanan Indonesia, 15(02), 58-64.
Nurlaila, S., Amellia, D., Sativa, O., Andayani, J. S. T., Ayesha, G. A. A., Putri, N. T., & Ridwan, H. (2026). Efektivitas ekstrak temulawak (Curcuma Xanthorrhiza) terhadap peningkatan nafsu makan anak: The effectiveness of temulawak extract (Curcuma Xanthorrhiza) on increasing children's appetite. Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing), 12(1), 81-89.
Oktaviyanti, S. (2024). # NOPUBLISH 30/9/2024# Pengaruh kombinasi ekstrak daun bungur (Langerstroemia speciosa) daun juwet (Syzygium Cuminni) dan rimpang temulawak (Curcuma xanthorriza) terhadap histopatologi hepar tikus (Rattus norvengicus) diabetes tipe ii (Doctoral dissertation, Universitas Islam Negeri Maulana Malik Ibrahim).
Pipit Miranti, I., Nur Cahyani, A., Hidayaturohman, E., Fathina Rifa, N., Farmasi dan Makanan, A., & Tinggi Ilmu Kesehatan Ibnu Sina Ajibarang, S. (2025). Efek Pemberian Infusa Kombinasi Temu Ireng, Temulawak, Kencur Dan Jahe Terhadap Berat Mencit Galur Swiss-Webster Ffect Of Giving A Combination Of Black Temu, Temulawak, Kencur And Ginger Infusion On The Weight Of Swiss-Webster Strain Mice. In Stigma (Vol. 18, Number 1).
Putri, N. P. A. E., & Leliqia, N. P. E. (2024). Studi Kandungan Fitokimia dan Potensi Antibakteri Ekstrak Rimpang Temulawak Secara in Vitro dengan Metode Mikrodilusi. In Prosiding Workshop dan Seminar Nasional Farmasi (Vol. 3, pp. 213-226).
Rahmi, M. A. B. (2025). Pengaruh Latihan Fisik Intensitas Sedang Terhadap Tumor Necrosis Factor-Alpha (TNF-α) Pada Tikus Wistar (Rattus norvegicus) Model Obesitas (Doctoral dissertation, Universitas Tadulako).
Sari, F., Akbar, N. D., Rifmawati, H., Ariyani, T. D., & Nuraini, N. (2025). Sosialisasi Pembuatan Permen Jelly Dari Ekstrak Kunyit (Curcumae Domestica) Dan Ekstrak Temulawak (Curcumae Xanthorriza) Untuk Mengatasi Gangguan Pencernaan Dan Nyeri Haid. Mosiraha: Jurnal Pengabdian Farmasi, 3(1), 44-53.
Skoracka, K., Hryhorowicz, S., Schulz, P., Zawada, A., Ratajczak-Pawłowska, A. E., Rychter, A. M., ... & Krela-Kaźmierczak, I. (2025). The role of leptin and ghrelin in the regulation of appetite in obesity. Peptides, 186, 171367.
Sransiska SP, S. (2024). Formulasi Mikrokapsul Kombinasi Ekstrak Temulawak (Curcuma xanthorrhiza Roxb.), Mengkudu U (Morinda citrifolia L.), dan Daun Sirsak (Annona muricata L.) sebagai Antiosidan.
Sri Mahasari, M., Agustina, L., & Widhi Astuti, K. E. (2025). Administration of Curcuma Xanthorrizha (Temulawak) Jelly Increases the Body Weight of Undernourished Toddlers. Jurnal Kebidanan Dan Kesehatan Tradisional, 9(1), 31–38. https://doi.org/10.37341/jkkt.v9i1.672
Van Egmond, L. T., Meth, E. M., Engström, J., Ilemosoglou, M., Keller, J. A., Vogel, H., & Benedict, C. (2023). Effects of acute sleep loss on leptin, ghrelin, and adiponectin in adults with healthy weight and obesity: A laboratory study. Obesity, 31(3), 635-641.
Nurjannah, S. (2021). Nilai-Nilai Akhlakul Karimah Menurut Abu Hasan Ali bin Muhammad bin Habib Al-Mawardi Dalam Buku Islam Happy Ending [UINUSKA Riau]. https://repository.uin-suska.ac.id/53564/1/FILE LENGKAP KECUALI HASIL PENELITIAN %28BAB IV%29.pdf .
Nursalam. (2006). Manajemen keperawatan. Salemba Medika.
Potter, P. et. a. (2025). Fundamentals of Nursing (12th ed.). Elsevier.
Sitorus, R. (2024). Model Praktek Keperawatan Profesional di Rumah Sakit dan Panduan Implementasi. Sagung Seto.
Sri Listiowati, E. a. (2023). Intervensi Mindfullness Terhadap Caring Perawat. Journal of Telenursing (JOTING), 5(2), 3470–3478. https://doi.org/https://doi.org/10.31539/joting.v5i2.7727
Sumarni, T. (2016). Hubungan Kecerdasan Emosional Dengan Perilaku Caring Pada Mahasiswa Keperawatan D3 Stikes Harapan Bangsa Purwokerto. Jurnal Kesehatan, Kebidanan Dan Keperawatan, 9(17), 83–94. https://doi.org/https://doi.org/10.35960/vm.v9i2.131
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