Potential Anti-Inflammatory Activity Of Kemangi Leaves (Ocimum Basillicum) in Reducing Folicel Atresia in Musmusculus Mencites Model Endometriosis

Ernawati Anggraeni; Ririn Handayani; Rizki Fitrianingtyas

doi:10.36858/jkds.v13i2.798

Authors

Ernawati Anggraeni Faculty of Health Science, Universitas dr. Soebandi
Ririn Handayani Faculty of Health Science, Universitas dr. Soebandi
Rizki Fitrianingtyas Faculty of Health Science, Universitas dr. Soebandi

DOI:

https://doi.org/10.36858/jkds.v13i2.798

Keywords:

Basil Leaf (Ocimum Basilicum),, endometriosis, folicular

Abstract

Endometriosis is ai chronic diseaise chairaicterized by the development of endometriail stromai. Paitients with endometriosis aire chairaicterized by pelvic paiin aind infertility, which is ai heailth threait to women aind aidolescents. Baisil leaives (Ocimuim baisillicuim) is ain airomaitic plaint thait contaiins citrail which is known to haive ainti-inflaimmaitory aictivity. The puirpose of this stuidy is to determine the decreaise in Folike Aitresiai in Mice Muismuiscuiluis Endometriosis Model. Methods: This stuidy uised experimentail reseairch with endometriosis mice thait were given graided dose treaitment theraipy aind then saiw ai decreaise in follicuilair aitresiai. The resuilts of the ainailysis of follicuilair aitresiai showed thait the aidministraition of ethainol extraict ofBaisil leaives (Ocimuim Baisilicuim) in the muiltilevel dose treaitment grouip wais clinicailly aible to reduice the aiveraige follicuilair aitresiai still below the control grouip, ailthouigh not staitisticailly significaint. The distribuition of follicuilair aitresiai daitai is not normailly distribuited so it is done with the Kruiskail Waillis test. The Kruiskail Waillis test resuilts showed ai vailuie of 0.187 (p>0.05). Concluision ainti- inflaimmaitory in baisil leaives (Ocimuim Baisilicuim) is aible to reduice follicuilair aitresiai in endometriosis model mice ailthouigh not staitisticailly significain so further research is needed regarding the duration of dosage administration.

Author Biography

Ririn Handayani, Faculty of Health Science, Universitas dr. Soebandi

please help riview my artikel

References

A’yuni, D. Q., Sa’adi, A., & Widjiati, W. (2023). Ethanol extract of basil (Ocimum Basilicum L.) leaves inhibits endometriosis growth in a mouse model by modulating vascular endothelial growth factor (VEGF) expression. Journal of Medicine and Life, 16(8), 1224–1230. https://doi.org/10.25122/jml-2023-0225

Alkhateeb, M. A., Al-Otaibi, W. R., AlGabbani, Q., Alsakran, A. A., Alnafjan, A. A., Alotaibi, A. M., & Al-Qahtani, W. S. (2021). Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells. Biological Research, 54(1), 1–10. https://doi.org/10.1186/s40659-020-00324-0

Amini, L., Chekini, R., Nateghi, M. R., Haghani, H., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2021). The Effect of Combined Vitamin C and Vitamin e Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. Pain Research and Management, 2021. https://doi.org/10.1155/2021/5529741

Andriyanto, A., Widi, L. N., Subangkit, M., Tarigan, E., Irarang, Y., Nengsih, R. F., & Manalu, W. (2022). Potential use of Indonesian basil (Ocimum basilicum) maceration to increase estradiol and progesterone synthesis and secretion to improve prenatal growth of offspring using female albino rats as an animal model. Veterinary World, 15(5), 1197–1207. https://doi.org/10.14202/vetworld.2022.1197-1207

Ashok Agarwal. (2017). Un modelo de probabilidad implementado en la solución de ruteo de autobuses escolares con selección de paradas. Dyna (Spain), 92(2), 138. https://doi.org/10.6036/8204

Barickman, T. C., Olorunwa, O. J., Sehgal, A., Walne, C. H., Reddy, K. R., & Gao, W. (2021). Yield, physiological performance, and phytochemistry of basil (Ocimum basilicum l.) under temperature stress and elevated co2 concentrations. Plants, 10(6). https://doi.org/10.3390/plants10061072

Bouic, P. J. D. (2023). Endometriosis and infertility: the hidden link between endometritis, hormonal imbalances and immune dysfunctions preventing implantation! Jornal Brasileiro de Reproducao Assistida, 27(2), 144–146. https://doi.org/10.5935/1518-0557.20230015

Chatgilialoglu, C. (2024). Biomarkers of Oxidative and Radical Stress. Biomolecules, 14(2), 1–7. https://doi.org/10.3390/biom14020194

Eftekhar, N., Moghimi, A., Mohammadian Roshan, N., Saadat, S., & Boskabady, M. H. (2019). Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma. BMC Complementary and Alternative Medicine, 19(1), 1–11. https://doi.org/10.1186/s12906-019-2765-4

Garcia-Gomez, E., Vazquez-Martinez, E. R., Reyes-Mayoral, C., Cruz-Orozco, O. P., Camacho-Arroyo, I., & Cerbón, M. (2020). Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis. Frontiers in Endocrinology, 10(January). https://doi.org/10.3389/fendo.2019.00935

Kapoor, R., Stratopoulou, C. A., & Dolmans, M. M. (2021). Pathogenesis of endometriosis: New insights into prospective therapies. International Journal of Molecular Sciences, 22(21), 1–14. https://doi.org/10.3390/ijms222111700

Karimah, F., Sa’adi, A., & Widjiati, W. (2023). The ethanolic extract of basic leaves (ocimum basilicum) effect on expression of follicle stimulating hormone receptors (FSHr) and folliculogenesis in female mice model endometriosis. Journal of Medicinal and Chemical Sciences, 6(12), 2896–2905. https://doi.org/10.26655/JMCHEMSCI.2023.12.4

Kinyoki, D., Osgood-Zimmerman, A. E., Bhattacharjee, N. V., Schaeffer, L. E., Lazzar-Atwood, A., Lu, D., Ewald, S. B., Donkers, K. M., Letourneau, I. D., Collison, M., Schipp, M. F., Abajobir, A., Abbasi, S., Abbasi, N., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., … Hay, S. I. (2021). Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018. Nature Medicine, 27(10), 1761–1782. https://doi.org/10.1038/s41591-021-01498-0

Kusumastuty, I., Adi, P., Budhi Harti, L., & Ari Nugroho, F. (2015). Pengaruh Pemberian Daun Ubi Jalar Ungu (Ipomoea batatas Lam) terhadap Kadar TNF-Α, Il-6 dan Nf-Κb pada Tikus yang Dipapar Asap Rokok. Jurnal Kedokteran Brawijaya, 28(3), 228–232. https://doi.org/10.21776/ub.jkb.2015.028.03.12

Matos, L. C., Machado, J. P., Monteiro, F. J., & Greten, H. J. (2021). Understanding traditional chinese medicine therapeutics: An overview of the basics and clinical applications. Healthcare (Switzerland), 9(3). https://doi.org/10.3390/healthcare9030257

Miller, J. E., Ahn, S. H., Monsanto, S. P., Khalaj, K., Koti, M., & Tayade, C. (2017). Oncotarget 7138 www.impactjournals.com/oncotarget Implications of immune dysfunction on endometriosis associated infertility. Oncotarget, 8(4), 7138–7147. www.impactjournals.com/oncotarget/

Nomden, M., Beljaars, L., Verkade, H. J., Hulscher, J. B. F., & Olinga, P. (2020). Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature. Frontiers in Medicine, 7(December), 1–16. https://doi.org/10.3389/fmed.2020.617261

Oala, I. E., Mitranovici, M. I., Chiorean, D. M., Irimia, T., Crișan, A. I., Melinte, I. M., Cotruș, T., Tudorache, V., Moraru, L., Moraru, R., Caravia, L., Morariu, M., & Pușcașiu, L. (2024). Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature. Diagnostics, 14(3), 1–17. https://doi.org/10.3390/diagnostics14030312

Santanam, N., Zoneraich, N., & Parthasarathy, S. (2017). Myeloperoxidase as a potential target in women with endometriosis undergoing IVF. Reproductive Sciences, 24(4), 619–626. https://doi.org/10.1177/1933719116667225

Santoso, B., Rahmawati, N. Y., Sa’adi, A., Dwiningsih, S. R., Annas, J. Y., Tunjungseto, A., Widyanugraha, M. Y. A., Mufid, A. F., & Ahsan, F. (2021). Elevated peritoneal soluble endoglin and GDF-15 in infertile women with severe endometriosis and pelvic adhesion. Journal of Reproductive Immunology, 146(May 2020), 103343. https://doi.org/10.1016/j.jri.2021.103343

Shan, J., Li, D. J., & Wang, X. Q. (2023). Towards a Better Understanding of Endometriosis-Related Infertility: A Review on How Endometriosis Affects Endometrial Receptivity. Biomolecules, 13(3). https://doi.org/10.3390/biom13030430

Singh, S., & Singh, T. G. (2020). Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach. Current Neuropharmacology, 18(10), 918–935. https://doi.org/10.2174/1570159x18666200207120949

Smolarz, B., Szyllo, K., & Romanowicz, H. (2021). Endometriosis: Epidemiology, classification, pathogenesis, treatment and genetics (review of literature). International Journal of Molecular Sciences, 22(19). https://doi.org/10.3390/ijms221910554

Symons, L. K., Miller, J. E., Kay, V. R., Marks, R. M., Liblik, K., Koti, M., & Tayade, C. (2018). The Immunopathophysiology of Endometriosis. Trends in Molecular Medicine, 24(9), 748–762. https://doi.org/10.1016/j.molmed.2018.07.004

Takeuchi, H., Takahashi-Muto, C., Nagase, M., Kassai, M., Tanaka-Yachi, R., & Kiyose, C. (2020). Anti-inflammatory effects of extracts of sweet basil (Ocimum basilicum l.) on a co-culture of 3t3-l1 adipocytes and raw264.7 macrophages. Journal of Oleo Science, 69(5), 487–493. https://doi.org/10.5650/jos.ess19321

Trisetiyono, Y., Widjiati, W., Hidayat, S. T., & Pramono, N. (2019). Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice. Journal of Biomedicine and Translational Research, 5(2), 53–61. https://doi.org/10.14710/jbtr.v5i2.4716

Vannuccini, S., Clemenza, S., Rossi, M., & Petraglia, F. (2022). Hormonal treatments for endometriosis: The endocrine background. Reviews in Endocrine and Metabolic Disorders, 23(3), 333–355. https://doi.org/10.1007/s11154-021-09666-w

Widyanugraha, M. A., Widjiati, W., & Hendarto, H. (2022). Effect of Endometriosis on Cumulus ATP, Number of Mitochondria and Oocyte Maturity in Cumulus Oocyte Complex in Mice. Revista Brasileira de Ginecologia e Obstetricia, 45(7), E393–E400. https://doi.org/10.1055/s-0043-1772186